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Cancer Treatment API Decitabine CAS 2353-33-5
10-1009 Gram
$30.00
≥ 1010 Gram
$20.00
- Item No. W&ZMOQ 10 Gram
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If over 500pcs, mass production will start until pre-production sample has been approved.
Est. 7 days production
Cancer Treatment API Decitabine CAS 2353-33-5
| Product Name | Decitabine |
| CAS No | 2353-33-5 |
| Formula | C8H12N4O4 |
| Purity | 98% by HPLC |
| Appearance | White powder |
What is Decitabine?
Decitabine is also known as 5- aza -2 '- deoxycytidine, 5- aza -2 '- deoxycytidine monophosphate, adenosine analogues is a natural 2' - deoxycytidine acid, by inhibiting DNA methyltransferase, reduced DNA methylation, thus inhibit the proliferation of tumor cells and prevent drug resistance. Is currently the strongest known methyl DNA specific inhibitor, which belongs to the S phase of the cell cycle specific drug for the treatment of myelodysplastic syndrome (MDS).
Demethylation drugs can activate tumor cell tumor suppressor genes and enhance the expression of regulatory genes such as differentiation genes, so that MDS can be used for the treatment of cancer. The 5- aza -2'- deoxy cytidine, which has been phosphorylated, exerts its antitumor effects. It acts directly on DNA and inhibits DNA methyltransferase, which causes DNA hypomethylation and cell differentiation and death. DNA inhibits DNA methylation in vitro, but does not affect the synthesis of dna. It can lead to demethylation of tumor cells and restore the normal function of genes, which is important for controlling cell differentiation and proliferation. However, non proliferating cells are insensitive to capecitabine.
Is a kind of epigenetic modification, can inhibit DNA methyltransferase activity, causing demethylation in DNA (methylation) and open chromatin remodeling by activating gene; when demethylation and histone acetylation when combined, synergistic activation gene 5 '- deoxycytidine; nitrogen DNA induced demethylation or semi demethylation; DNA demethylation can regulate gene expression, can improve the quality of nuclease sensitivity detection structure through the "open" staining, the remodeling of chromatin structure, allowing transcription factor connection gene promoter, transcription complex assembly and gene expression
There is an antitumor activity in the lung, and it is a dual mechanism of dose difference. It has cytotoxicity at high concentration and demethylation at low concentration. Acting on proliferating (stage S) cells.
Applications:
Cyproterone acetate has antagonistic properties towards the 5-Aza-2'-Deoxycytidine, has been reported to cause phosphorylation inhibition of 2'-deoxycytidine in certain cells and the incorporation of 2'-deoxycytidine into DNA. Experiments have shown that this compound induces changes in the differentiated state of cultured mouse embryo cells and additionally inhibits Dnmt (DNA methyltransferase). DNA methylation has been noted to be important in determining apoptotic susceptibility to histone deacetylase inhibitors, and its prevention can cause gene silencing and transcriptional repression. Other studies suggest that cell exposure to 5-Aza-2'-Deoxycytidine causes a change in replication timing, reactivation of repressed genes, and decondensation of heterochromatin. Furthermore, this agent demonstrates the ability to induce histone hyperacetylation in murine centromeric heterochromatin and also affect intranuclear distribution of histone deacetylase 2.
Packaging Details
| 1kg/bag | N.W 1KG, G.W 1.1KG, packed in an aluminum foil bag |
| 5kg/carton | N.W 1KG, G.W 1.1KG, packed in 5 aluminum foil bag |
| 25kg/drum | N.W 25KG, G.W 28KG, packed in a cardboard-drum with 2 plastic-bags inside; Drum Size: 510mm high, 360mm diameter |
Shipment Method
| BY Express | By Air | By Sea |
| Suitable for for package under 45kgs | Suitable for package more than 45kgs | Suitable for package more than 500kgs |
| about 3~7 days | about 3~7 days | about 7~45 days |
| Door to Door | Port to Port | Port to Port |
| High Cost | Medium Cost | Low Cost |
| Business Type | Trading Company | Country / Region | Hubei, China |
| Main Products | Nutritional Supplements,herbal extract,API & Intermediates,peptides,nootropics | Total Employees | 11 - 50 People |
| Total Annual Revenue | Above US$100 Million | Year Established | 2017 |
| Certifications | Product Certifications | ||
| Patents | Trademarks | ||
| Main Markets | North America 30% Western Europe 20% South America 10% | ||
Wuhan W&Z Biotech Co,.Ltd is a high-tech enterprise which focus on the R&D, production, sales and service of biomedical and large health field. It has strong scientific research strength, modern management system and high-quality marketing team.
W&Z, located in Wuhan, the national key science and education base, cooperates with Wuhan University, Huazhong University of Science and Technology and other well-known universities, forming a good R&D and production team. in our R & D team, there are five experts in fields.
W&Z focus on provide CRO and CMO services for customers on one-stop intermediates, APIs and green technology. We have established modern R&d laboratories in Wuhan Optical Valley, have two partner factories in Shandong and Sichuan. Besides supplying standard products with mature technology, we also do customize under customer`s personalized needs.
We will uphold the quality first, service-oriented, integrity-based purpose, committed to provide more and more, better and better services to the global customers.
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